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No, it’s not Secure to just take an 80-mg dose of Cialis. The utmost advisable each day dosage of Cialis is twenty mg per day if you take it as needed for ED. If you are taking Cialis every day, the utmost dosage is 5 mg a day.No dose adjustment is warranted. The lessened exposure of tadalafil With all the coadministration of rifampin or other CY